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What is the most important information I should know about clopidogrel?

Clopidogrel keeps your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Because of this action of the drug, clopidogrel, it may be easier for you to bleed, even a minor injury. Contact your doctor or seek emergency medical care if you have bleeding that does not stop.

You can also have bleeding inside your body, as in the stomach or intestines. Call your doctor immediately if you have bloody or black stools, or if you cough up blood or vomit that looks like coffee grounds. These could be signs of bleeding in the digestive tract. Avoid alcohol while taking clopidogrel. Alcohol may increase the risk of bleeding in the stomach or intestines.

If you need to have any type of surgery or dental work, tell the doctor or dentist in advance that you are using clopidogrel. You may need to stop using the drug for at least 5 days before surgery to prevent excessive bleeding.

If you are taking clopidogrel, do not take aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs) without the advice of your doctor. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen ( Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

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